β-Endorphin attenuates collagen-induced arthritis partially by inhibiting peripheral pro-inflammatory mediators
نویسندگان
چکیده
منابع مشابه
β-Endorphin attenuates collagen-induced arthritis partially by inhibiting peripheral pro-inflammatory mediators.
The classical analgesic pathway of opioids by binding their receptors in the nervous system is well known. However, little is known regarding opioid analgesia through the anti-inflammatory pathway. The present study aimed to investigate the analgesic and anti-inflammatory effect of β-endorphin on inflammatory pain. A rat model of collagen-induced arthritis (CIA) was generated by intradermal inj...
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OBJECTIVE To observe the effects and mechanisms of beta-endorphin (beta-END) preventing collagen induced arthritis (CIA) by neuroimmuno-regulating pathway. METHODS Female wistar (Ws) rats were used in this study. CIA was induced by Native bovine type II collagen emulsified with complete Freund's adjuvant (CFA). Beta-END was administered i.p. to CIA rats every other day from the 14th day (seco...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2018
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2018.5914